The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model

par Chen, Chunli, Ortega, Fatima, Rullas, Joaquin, Alameda, Laura, Angulo-Barturen, Iñigo, Ferrer, Santiago, Simonsson, Ulrika SH
Publié dans J Pharmacokinet Pharmacodyn (2017)

Assessing Pharmacodynamic Interactions in Mice Using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models

par Chen, Chunli, Wicha, Sebastian G., de Knegt, Gerjo J., Ortega, Fatima, Alameda, Laura, Sousa, Veronica, de Steenwinkel, Jurriaan E. M., Simonsson, Ulrika S. H.
Publié dans CPT Pharmacometrics Syst Pharmacol (2017)

A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity

par Ganapathy, Uday S., González del Rio, Rubén, Cacho-Izquierdo, Mónica, Ortega, Fátima, Lelièvre, Joël, Barros-Aguirre, David, Lindman, Marissa, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Publié dans Antimicrob Agents Chemother (2021)

A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis

par Kumar, Anuradha, Guardia, Ana, Colmenarejo, Gonzalo, Pérez, Esther, Gonzalez, Ruben R., Torres, Pedro, Calvo, David, Gómez, Ruben M., Ortega, Fátima, Jiménez, Elena, Gabarro, Raquel C., Rullás, Joaquín, Ballell, Lluis, Sherman, David R.
Publié dans ACS Infect Dis (2015)

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

par Poce, Giovanna, Bates, Robert H., Alfonso, Salvatore, Cocozza, Martina, Porretta, Giulio Cesare, Ballell, Lluís, Rullas, Joaquin, Ortega, Fátima, De Logu, Alessandro, Agus, Emanuela, La Rosa, Valentina, Pasca, Maria Rosalia, De Rossi, Edda, Wae, Baojie, Franzblau, Scott G., Manetti, Fabrizio, Botta, Maurizio, Biava, Mariangela
Publié 2013

Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign

par Diaz, Rosario, Luengo-Arratta, Sandra A., Seixas, João D., Amata, Emanuele, Devine, William, Cordon-Obras, Carlos, Rojas-Barros, Domingo I., Jimenez, Elena, Ortega, Fatima, Crouch, Sabrinia, Colmenarejo, Gonzalo, Fiandor, Jose Maria, Martin, Jose Julio, Berlanga, Manuela, Gonzalez, Silvia, Manzano, Pilar, Navarro, Miguel, Pollastri, Michael P.
Publié 2014

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

par Martínez-Hoyos, María, Perez-Herran, Esther, Gulten, Gulcin, Encinas, Lourdes, Álvarez-Gómez, Daniel, Alvarez, Emilio, Ferrer-Bazaga, Santiago, García-Pérez, Adolfo, Ortega, Fátima, Angulo-Barturen, Iñigo, Rullas-Trincado, Joaquin, Blanco Ruano, Delia, Torres, Pedro, Castañeda, Pablo, Huss, Sophie, Fernández Menéndez, Raquel, González del Valle, Silvia, Ballell, Lluis, Barros, David, Modha, Sundip, Dhar, Neeraj, Signorino-Gelo, François, McKinney, John D., García-Bustos, Jose Francisco, Lavandera, Jose Luis, Sacchettini, James C., Jimenez, M. Soledad, Martín-Casabona, Nuria, Castro-Pichel, Julia, Mendoza-Losana, Alfonso
Publié dans EBioMedicine (2016)