Assessing Pharmacodynamic Interactions in Mice Using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models

The aim of this study was to investigate pharmacodynamic (PD) interactions in mice infected with Mycobacterium tuberculosis using population pharmacokinetics (PKs), the Multistate Tuberculosis Pharmacometric (MTP) model, and the General Pharmacodynamic Interaction (GPDI) model. Rifampicin, isoniazid...

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Bibliografische gegevens
Gepubliceerd in:CPT Pharmacometrics Syst Pharmacol
Hoofdauteurs: Chen, Chunli, Wicha, Sebastian G., de Knegt, Gerjo J., Ortega, Fatima, Alameda, Laura, Sousa, Veronica, de Steenwinkel, Jurriaan E. M., Simonsson, Ulrika S. H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702905/
https://ncbi.nlm.nih.gov/pubmed/28657202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12226
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