mmpL7 Gene of Mycobacterium tuberculosis Is Responsible for Isoniazid Efflux in Mycobacterium smegmatis

The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter, confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (...

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Autori principali: Pasca, Maria R., Guglierame, Paola, De Rossi, Edda, Zara, Francesca, Riccardi, Giovanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280163/
https://ncbi.nlm.nih.gov/pubmed/16251328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.11.4775-4777.2005
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