Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis

The increasing occurrence of multidrug-resistant Mycobacterium tuberculosis (Mtb) is a serious threat to global public health. Among the many mechanisms of drug resistance, only resistance-nodulation-division (RND)-type multidrug efflux systems can simultaneously render bacteria tolerant to numerous...

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Veröffentlicht in:mSphere
Hauptverfasser: Yamamoto, Kentaro, Nakata, Noboru, Mukai, Tetsu, Kawagishi, Ikuro, Ato, Manabu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845600/
https://ncbi.nlm.nih.gov/pubmed/33408221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00518-20
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