Cancer epigenetics drug discovery and development: the challenge of hitting the mark

Por Campbell, Robert M., Tummino, Peter J.
Publicado em 2014

Cancer epigenetics drug discovery and development: the challenge of hitting the mark

Por Campbell, Robert M., Tummino, Peter J.
Publicado em 2014

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13

Por Gooljarsingh, Lata T., Lakdawala, Ami, Coppo, Frank, Luo, Lusong, Fields, Gregg B., Tummino, Peter J., Gontarek, Richard R.
Publicado em 2008

ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches

Por Li, Hua, Bitler, Benjamin G., Vathipadiekal, Vinod, Maradeo, Marie E., Slifker, Michael, Creasy, Caretha L., Tummino, Peter J., Cairns, Paul, Birrer, Michael J., Zhang, Rugang
Publicado em 2011

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

Por Wyce, Anastasia, Degenhardt, Yan, Bai, Yuchen, Le, BaoChau, Korenchuk, Susan, Crouthamel, Ming-Chih, McHugh, Charles F., Vessella, Robert, Creasy, Caretha L., Tummino, Peter J., Barbash, Olena
Publicado em 2013

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues

Por Gooljarsingh, Lata T., Fernandes, Christine, Yan, Kang, Zhang, Hong, Grooms, Michael, Johanson, Kyung, Sinnamon, Robert H., Kirkpatrick, Robert B., Kerrigan, John, Lewis, Tia, Arnone, Marc, King, Alastair J., Lai, Zhihong, Copeland, Robert A., Tummino, Peter J.
Publicado em 2006

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

Por Van Aller, Glenn S., Reynoird, Nicolas, Barbash, Olena, Huddleston, Michael, Liu, Shichong, Zmoos, Anne-Flore, McDevitt, Patrick, Sinnamon, Robert, Le, BaoChau, Mas, Gloria, Annan, Roland, Sage, Julien, Garcia, Benjamin A., Tummino, Peter J., Gozani, Or, Kruger, Ryan G.
Publicado em 2012

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Por Mazur, Pawel K., Reynoird, Nicolas, Khatri, Purvesh, Jansen, Pascal W.T.C., Wilkinson, Alex, Liu, Shichong, Barbash, Olena, Van Aller, Glenn S., Huddleston, Michael, Dhanak, Dashyant, Tummino, Peter J., Kruger, Ryan G., Garcia, Benjamin, Butte, Atul J., Vermeulen, Michiel, Sage, Julien, Gozani, Or
Publicado em 2014

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

Por Wyce, Anastasia, Ganji, Gopinath, Smitheman, Kimberly N., Chung, Chun-wa, Korenchuk, Susan, Bai, Yuchen, Barbash, Olena, Le, BaoChau, Craggs, Peter D., McCabe, Michael T., Kennedy-Wilson, Karen M., Sanchez, Lydia V., Gosmini, Romain L., Parr, Nigel, McHugh, Charles F., Dhanak, Dashyant, Prinjha, Rab K., Auger, Kurt R., Tummino, Peter J.
Publicado em 2013

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

Por McCabe, Michael T., Graves, Alan P., Ganji, Gopinath, Diaz, Elsie, Halsey, Wendy S., Jiang, Yong, Smitheman, Kimberly N., Ott, Heidi M., Pappalardi, Melissa B., Allen, Kimberly E., Chen, Stephanie B., Della Pietra, Anthony, Dul, Edward, Hughes, Ashley M., Gilbert, Seth A., Thrall, Sara H., Tummino, Peter J., Kruger, Ryan G., Brandt, Martin, Schwartz, Benjamin, Creasy, Caretha L.
Publicado em 2012

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

Por Verma, Sharad K., Tian, Xinrong, LaFrance, Louis V., Duquenne, Céline, Suarez, Dominic P., Newlander, Kenneth A., Romeril, Stuart P., Burgess, Joelle L., Grant, Seth W., Brackley, James A., Graves, Alan P., Scherzer, Daryl A., Shu, Art, Thompson, Christine, Ott, Heidi M., Aller, Glenn S. Van, Machutta, Carl A., Diaz, Elsie, Jiang, Yong, Johnson, Neil W., Knight, Steven D., Kruger, Ryan G., McCabe, Michael T., Dhanak, Dashyant, Tummino, Peter J., Creasy, Caretha L., Miller, William H.
Publicado em 2012

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Por Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant
Publicado em 2010