Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist

Por Erickson-Miller, Connie L, Delorme, Evelyne, Tian, Shin-Shay, Hopson, Christopher B, Landis, Amy J, Valoret, Elizabeth I, Sellers, Teresa S, Rosen, Jon, Miller, Stephen G, Luengo, Juan I, Duffy, Kevin J, Jenkins, Julian M
Publicado em 2009

[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors

Por Yu, Hongyi, Moore, Michael L., Erhard, Karl, Hardwicke, Mary Ann, Lin, Hong, Luengo, Juan I., McSurdy-Freed, Jeanelle, Plant, Ramona, Qu, Junya, Raha, Kaushik, Rominger, Cynthia M., Schaber, Michael D., Spengler, Michael D., Rivero, Ralph A.
Publicado em 2013

Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors

Por Lin, Hong, Schulz, Mark J., Xie, Ren, Zeng, Jin, Luengo, Juan I., Squire, Michael D., Tedesco, Rosanna, Qu, Junya, Erhard, Karl, Mack, James F., Raha, Kaushik, Plant, Ramona, Rominger, Cynthia M., Ariazi, Jennifer L., Sherk, Christian S., Schaber, Michael D., McSurdy-Freed, Jeanelle, Spengler, Michael D., Davis, Charles B., Hardwicke, Mary Ann, Rivero, Ralph A.
Publicado em 2012

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

Por Lin, Hong, Zeng, Jin, Xie, Ren, Schulz, Mark J., Tedesco, Rosanna, Qu, Junya, Erhard, Karl F., Mack, James F., Raha, Kaushik, Rendina, Alan R., Szewczuk, Lawrence M., Kratz, Patricia M., Jurewicz, Anthony J., Cecconie, Ted, Martens, Stan, McDevitt, Patrick J., Martin, John D., Chen, Stephenie B., Jiang, Yong, Nickels, Leng, Schwartz, Benjamin J., Smallwood, Angela, Zhao, Baoguang, Campobasso, Nino, Qian, Yanqiu, Briand, Jacques, Rominger, Cynthia M., Oleykowski, Catherine, Hardwicke, Mary Ann, Luengo, Juan I.
Publicado no ACS Med Chem Lett (2015)

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Por Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant
Publicado em 2010