Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

Por Yang, Hongfang, Medeiros, Patricia F., Raha, Kaushik, Elkins, Patricia, Lind, Kenneth E., Lehr, Ruth, Adams, Nicholas D., Burgess, Joelle L., Schmidt, Stanley J., Knight, Steven D., Auger, Kurt R., Schaber, Michael D., Franklin, G. Joseph, Ding, Yun, DeLorey, Jennifer L., Centrella, Paolo A., Mataruse, Sibongile, Skinner, Steven R., Clark, Matthew A., Cuozzo, John W., Evindar, Ghotas
Publicado no ACS Med Chem Lett (2015)

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

Por Verma, Sharad K., Tian, Xinrong, LaFrance, Louis V., Duquenne, Céline, Suarez, Dominic P., Newlander, Kenneth A., Romeril, Stuart P., Burgess, Joelle L., Grant, Seth W., Brackley, James A., Graves, Alan P., Scherzer, Daryl A., Shu, Art, Thompson, Christine, Ott, Heidi M., Aller, Glenn S. Van, Machutta, Carl A., Diaz, Elsie, Jiang, Yong, Johnson, Neil W., Knight, Steven D., Kruger, Ryan G., McCabe, Michael T., Dhanak, Dashyant, Tummino, Peter J., Creasy, Caretha L., Miller, William H.
Publicado em 2012

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Por Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant
Publicado em 2010

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

Por Qian, Xiangping, McDonald, Andrew, Zhou, Han-Jie, Adams, Nicholas D., Parrish, Cynthia A., Duffy, Kevin J., Fitch, Duke M., Tedesco, Rosanna, Ashcraft, Luke W., Yao, Bing, Jiang, Hong, Huang, Jennifer K., Marin, Melchor V., Aroyan, Carrie E., Wang, Jianchao, Ahmed, Seyed, Burgess, Joelle L., Chaudhari, Amita M., Donatelli, Carla A., Darcy, Michael G., Ridgers, Lance H., Newlander, Ken A., Schmidt, Stanley J., Chai, Deping, Colón, Mariela, Zimmerman, Michael N., Lad, Latesh, Sakowicz, Roman, Schauer, Stephen, Belmont, Lisa, Baliga, Ramesh, Pierce, Daniel W., Finer, Jeffrey T., Wang, Zhengping, Morgan, Bradley P., Morgans, David J., Auger, Kurt R., Sung, Chiu-Mei, Carson, Jeff D., Luo, Lusong, Hugger, Erin D., Copeland, Robert A., Sutton, David, Elliott, John D., Jackson, Jeffrey R., Wood, Kenneth W., Dhanak, Dashyant, Bergnes, Gustave, Knight, Steven D.
Publicado em 2010