Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

di McCabe, Michael T., Graves, Alan P., Ganji, Gopinath, Diaz, Elsie, Halsey, Wendy S., Jiang, Yong, Smitheman, Kimberly N., Ott, Heidi M., Pappalardi, Melissa B., Allen, Kimberly E., Chen, Stephanie B., Della Pietra, Anthony, Dul, Edward, Hughes, Ashley M., Gilbert, Seth A., Thrall, Sara H., Tummino, Peter J., Kruger, Ryan G., Brandt, Martin, Schwartz, Benjamin, Creasy, Caretha L.
Pubblicazione 2012

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

di Drew, Allison E., Moradei, Oscar, Jacques, Suzanne L., Rioux, Nathalie, Boriack-Sjodin, Ann P., Allain, Christina, Scott, Margaret Porter, Jin, Lei, Raimondi, Alejandra, Handler, Jessica L., Ott, Heidi M., Kruger, Ryan G., McCabe, Michael T., Sneeringer, Christopher, Riera, Thomas, Shapiro, Gideon, Waters, Nigel J., Mitchell, Lorna H., Duncan, Kenneth W., Moyer, Mikel P., Copeland, Robert A., Smith, Jesse, Chesworth, Richard, Ribich, Scott A.
Pubblicato in Sci Rep (2017)

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

di Verma, Sharad K., Tian, Xinrong, LaFrance, Louis V., Duquenne, Céline, Suarez, Dominic P., Newlander, Kenneth A., Romeril, Stuart P., Burgess, Joelle L., Grant, Seth W., Brackley, James A., Graves, Alan P., Scherzer, Daryl A., Shu, Art, Thompson, Christine, Ott, Heidi M., Aller, Glenn S. Van, Machutta, Carl A., Diaz, Elsie, Jiang, Yong, Johnson, Neil W., Knight, Steven D., Kruger, Ryan G., McCabe, Michael T., Dhanak, Dashyant, Tummino, Peter J., Creasy, Caretha L., Miller, William H.
Pubblicazione 2012

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

di Béguelin, Wendy, Popovic, Relja, Teater, Matt, Jiang, Yanwen, Bunting, Karen L., Rosen, Monica, Shen, Hao, Yang, Shao Ning, Wang, Ling, Ezponda, Teresa, Martinez-Garcia, Eva, Zhang, Haikuo, Zhang, Yupeng, Verma, Sharad K., McCabe, Michael T., Ott, Heidi M., Van Aller, Glenn S., Kruger, Ryan G., Liu, Yan, McHugh, Charles F., Scott, David W., Chung, Young Rock, Kelleher, Neil, Shaknovich, Rita, Creasy, Caretha L., Gascoyne, Randy D., Wong, Kwok-Kin, Cerchietti, Leandro C., Levine, Ross L., Abdel-Wahab, Omar, Licht, Jonathan D., Elemento, Olivier, Melnick, Ari M.
Pubblicazione 2013