Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

by Gerhart, Sarah V., Kellner, Wendy A., Thompson, Christine, Pappalardi, Melissa B., Zhang, Xi-Ping, Montes de Oca, Rocio, Penebre, Elayne, Duncan, Kenneth, Boriack-Sjodin, Ann, Le, BaoChau, Majer, Christina, McCabe, Michael T., Carpenter, Chris, Johnson, Neil, Kruger, Ryan G., Barbash, Olena
Published in Sci Rep (2018)

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subt...

by Smitheman, Kimberly N., Severson, Tesa M., Rajapurkar, Satyajit R., McCabe, Michael T., Karpinich, Natalie, Foley, James, Pappalardi, Melissa B., Hughes, Ashley, Halsey, Wendy, Thomas, Elizabeth, Traini, Christopher, Federowicz, Kelly E., Laraio, Jenny, Mobegi, Fredrick, Ferron-Brady, Geraldine, Prinjha, Rabinder K., Carpenter, Christopher L., Kruger, Ryan G., Wessels, Lodewyk, Mohammad, Helai P.
Published in Haematologica (2019)

Dnmt1 has de novo activity targeted to transposable elements

by Haggerty, Chuck, Kretzmer, Helene, Riemenschneider, Christina, Kumar, Abhishek Sampath, Mattei, Alexandra L., Bailly, Nina, Gottfreund, Judith, Giesselmann, Pay, Weigert, Raha, Brändl, Björn, Giehr, Pascal, Buschow, René, Galonska, Christina, von Meyenn, Ferdinand, Pappalardi, Melissa B., McCabe, Michael T., Wittler, Lars, Giesecke-Thiel, Claudia, Mielke, Thorsten, Meierhofer, David, Timmermann, Bernd, Müller, Franz-Josef, Walter, Jörn, Meissner, Alexander
Published in Nat Struct Mol Biol (2021)

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

by McCabe, Michael T., Graves, Alan P., Ganji, Gopinath, Diaz, Elsie, Halsey, Wendy S., Jiang, Yong, Smitheman, Kimberly N., Ott, Heidi M., Pappalardi, Melissa B., Allen, Kimberly E., Chen, Stephanie B., Della Pietra, Anthony, Dul, Edward, Hughes, Ashley M., Gilbert, Seth A., Thrall, Sara H., Tummino, Peter J., Kruger, Ryan G., Brandt, Martin, Schwartz, Benjamin, Creasy, Caretha L.
Published 2012

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

by Gilmartin, Aidan G., Groy, Arthur, Gore, Elizabeth R., Atkins, Charity, Long, Edward R., Montoute, Monica N., Wu, Zining, Halsey, Wendy, McNulty, Dean E., Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa B., Kruger, Ryan G., McCabe, Michael T., Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B.
Published in Haematologica (2020)