In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of β-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2′-deoxycytidine (decitabine) have been shown to induce...

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書誌詳細
出版年:Haematologica
主要な著者: Gilmartin, Aidan G., Groy, Arthur, Gore, Elizabeth R., Atkins, Charity, Long, Edward R., Montoute, Monica N., Wu, Zining, Halsey, Wendy, McNulty, Dean E., Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa B., Kruger, Ryan G., McCabe, Michael T., Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B.
フォーマット: Artigo
言語:Inglês
出版事項: Fondazione Ferrata Storti 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252945/
https://ncbi.nlm.nih.gov/pubmed/32586904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2020.248658
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