In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of β-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2′-deoxycytidine (decitabine) have been shown to induce...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Haematologica
Huvudupphovsmän: Gilmartin, Aidan G., Groy, Arthur, Gore, Elizabeth R., Atkins, Charity, Long, Edward R., Montoute, Monica N., Wu, Zining, Halsey, Wendy, McNulty, Dean E., Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa B., Kruger, Ryan G., McCabe, Michael T., Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Fondazione Ferrata Storti 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252945/
https://ncbi.nlm.nih.gov/pubmed/32586904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2020.248658
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk