Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes

Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1, has previously been described. Inhibition of LS...

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Veröffentlicht in:Haematologica
Hauptverfasser: Smitheman, Kimberly N., Severson, Tesa M., Rajapurkar, Satyajit R., McCabe, Michael T., Karpinich, Natalie, Foley, James, Pappalardi, Melissa B., Hughes, Ashley, Halsey, Wendy, Thomas, Elizabeth, Traini, Christopher, Federowicz, Kelly E., Laraio, Jenny, Mobegi, Fredrick, Ferron-Brady, Geraldine, Prinjha, Rabinder K., Carpenter, Christopher L., Kruger, Ryan G., Wessels, Lodewyk, Mohammad, Helai P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545850/
https://ncbi.nlm.nih.gov/pubmed/30514804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.199190
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