CD4(+) T cell help creates memory CD8(+) T cells with innate and help-independent recall capacities

CD4(+) T cell help is required for the generation of CD8(+) cytotoxic T lymphocyte (CTL) memory. Here, we use genome-wide analyses to show how CD4(+) T cell help delivered during priming promotes memory differentiation of CTLs. Help signals enhance IL-15-dependent maintenance of central memory T (T(...

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Publicado no:Nat Commun
Main Authors: Ahrends, Tomasz, Busselaar, Julia, Severson, Tesa M., Bąbała, Nikolina, de Vries, Evert, Bovens, Astrid, Wessels, Lodewyk, van Leeuwen, Fred, Borst, Jannie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892909/
https://ncbi.nlm.nih.gov/pubmed/31797935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13438-1
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