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Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion

Persistent antigen exposure in chronic infection and cancer has been proposed to lead to cytotoxic T lymphocyte (CTL) “exhaustion”, i.e., loss of effector function and disease control. Recent work identifies a population of poorly differentiated TCF-1(+)PD-1(+) CD8(+) T cells as precursors of the te...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Busselaar, Julia, Tian, Sun, van Eenennaam, Hans, Borst, Jannie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573232/
https://ncbi.nlm.nih.gov/pubmed/33123174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.592569
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