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Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion
Persistent antigen exposure in chronic infection and cancer has been proposed to lead to cytotoxic T lymphocyte (CTL) “exhaustion”, i.e., loss of effector function and disease control. Recent work identifies a population of poorly differentiated TCF-1(+)PD-1(+) CD8(+) T cells as precursors of the te...
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| 出版年: | Front Immunol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7573232/ https://ncbi.nlm.nih.gov/pubmed/33123174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.592569 |
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