Helpless Priming Sends CD8+ T Cells on the Road to Exhaustion

Persistent antigen exposure in chronic infection and cancer has been proposed to lead to cytotoxic T lymphocyte (CTL) “exhaustion”, i.e., loss of effector function and disease control. Recent work identifies a population of poorly differentiated TCF-1+PD-1+ CD8+ T cells as precursors of the terminal...

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Autori principali: Julia Busselaar, Sun Tian, Hans van Eenennaam, Jannie Borst
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-10-01
Serie:Frontiers in Immunology
Soggetti:
CD8+ T cell
CD4+ T cell
exhaustion
dysfunction
cancer
infection
Accesso online:https://www.frontiersin.org/article/10.3389/fimmu.2020.592569/full
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