Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells

Hypoxia, angiogenesis, and immunosuppression have been proposed to be interrelated events that fuel tumor progression and impair the clinical effectiveness of anti-tumor therapies. Here we present new mechanistic data highlighting the role of hypoxia in fine-tuning CD8 T cell exhaustion in vitro, in...

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Publicat a:Front Immunol
Autors principals: Bannoud, Nadia, Dalotto-Moreno, Tomás, Kindgard, Lucía, García, Pablo A., Blidner, Ada G., Mariño, Karina V., Rabinovich, Gabriel A., Croci, Diego O.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137905/
https://ncbi.nlm.nih.gov/pubmed/34025660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.660944
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