Exhaustion of the CD8(+) T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta

Pathogenic gain-of-function mutations in the gene encoding phosphoinositide 3-kinase delta (PI3Kδ) cause activated PI3Kδ syndrome (APDS), a disease characterized by humoral immunodeficiency, lymphadenopathy, and an inability to control persistent viral infections including Epstein–Barr virus (EBV) a...

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Publicado en:Front Immunol
Autores principales: Wentink, Marjolein W. J., Mueller, Yvonne M., Dalm, Virgil A. S. H., Driessen, Gertjan J., van Hagen, P. Martin, van Montfrans, Joris M., van der Burg, Mirjam, Katsikis, Peter D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845988/
https://ncbi.nlm.nih.gov/pubmed/29563914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00446
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