MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers

BET inhibitors exhibit broad activity in cancer models, making predictive biomarkers challenging to define. Here we investigate the biomarkers of activity of the clinical BET inhibitor GSK525762 (I-BET; I-BET762) across cancer cell lines and demonstrate that KRAS mutations are novel resistance bioma...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Wyce, Anastasia, Matteo, Jeanne J., Foley, Shawn W., Felitsky, Daniel J., Rajapurkar, Satyajit R., Zhang, Xi-Ping, Musso, Melissa C., Korenchuk, Susan, Karpinich, Natalie O., Keenan, Kathryn M., Stern, Melissa, Mathew, Lijoy K., McHugh, Charles F., McCabe, Michael T., Tummino, Peter J., Kruger, Ryan G., Carpenter, Christopher, Barbash, Olena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908790/
https://ncbi.nlm.nih.gov/pubmed/29674704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0043-9
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados