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Limited Anti-Tumor Activity of Combined BET and MEK Inhibition in Neuroblastoma

BACKGROUND: The treatment of high-risk neuroblastoma continues to present a formidable challenge to pediatric oncology. Previous studies have shown that BET (Bromodomain and extra-terminal) inhibitors can inhibit MYCN expression and suppress MYCN-amplified neuroblastoma in vivo. Furthermore, alterat...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Healy, Jason R., Hart, Lori S., Shazad, Alexander L., Gagliardi, Maria E., Tsang, Matthew, Elias, Jimmy, Ruden, Jacob, Farrel, Alvin, Rokita, Jo Lynne, Li, Yimei, Wyce, Anastasia, Barbash, Olena, Batra, Vandana, Samanta, Minu, Maris, John M., Schnepp, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188563/
https://ncbi.nlm.nih.gov/pubmed/32307821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.28267
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