Limited Anti-Tumor Activity of Combined BET and MEK Inhibition in Neuroblastoma

BACKGROUND: The treatment of high-risk neuroblastoma continues to present a formidable challenge to pediatric oncology. Previous studies have shown that BET (Bromodomain and extra-terminal) inhibitors can inhibit MYCN expression and suppress MYCN-amplified neuroblastoma in vivo. Furthermore, alterat...

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Udgivet i:Pediatr Blood Cancer
Main Authors: Healy, Jason R., Hart, Lori S., Shazad, Alexander L., Gagliardi, Maria E., Tsang, Matthew, Elias, Jimmy, Ruden, Jacob, Farrel, Alvin, Rokita, Jo Lynne, Li, Yimei, Wyce, Anastasia, Barbash, Olena, Batra, Vandana, Samanta, Minu, Maris, John M., Schnepp, Robert W.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188563/
https://ncbi.nlm.nih.gov/pubmed/32307821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.28267
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