PARP-1–Targeted Auger Emitters Display High-LET Cytotoxic Properties In Vitro but Show Limited Therapeutic Utility in Solid Tumor Models of Human Neuroblastoma

The currently available therapeutic radiopharmaceutical for high-risk neuroblastoma, (131)I-metaiodobenzylguanidine, is ineffective at targeting micrometastases because of the low–linear-energy-transfer (LET) properties of high-energy β-particles. In contrast, Auger radiation has high-LET properties...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Nucl Med
Prif Awduron: Lee, Hwan, Riad, Aladdin, Martorano, Paul, Mansfield, Adam, Samanta, Minu, Batra, Vandana, Mach, Robert H., Maris, John M., Pryma, Daniel A., Makvandi, Mehran
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society of Nuclear Medicine 2020
Pynciau:
Oncology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262217/
https://ncbi.nlm.nih.gov/pubmed/31676730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.119.233965
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