Targeting PARP-1 with alpha-particles is potently cytotoxic to human neuroblastoma in pre-clinical models

Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but cellular lethality could be further enhanced by targeting alpha-emitters directly to the nucleus. Poly(ADP-ribose) polymerase (PARP) 1 is a druggable protein in the nucleus that is overexpressed in neurobla...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cancer Ther
Egile Nagusiak: Makvandi, Mehran, Lee, Hwan, Puentes, Laura N., Reilly, Sean W., Rathi, Komal S., Weng, Chi-Chang, Chan, Ho Sze, Hou, Catherine, Raman, Pichai, Martinez, Daniel, Xu, Kuiying, Carlin, Sean D., Greenberg, Roger A., Pawel, Bruce R., Mach, Robert H., Maris, John M., Pryma, Daniel A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606392/
https://ncbi.nlm.nih.gov/pubmed/31072830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0837
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