Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

BET (bromodomain and extra-terminal) proteins regulate gene expression through their ability to bind to acetylated chromatin and subsequently activate RNA PolII-driven transcriptional elongation. Small molecule BET inhibitors prevent binding of BET proteins to acetylated histones and inhibit transcr...

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Autores principales: Wyce, Anastasia, Degenhardt, Yan, Bai, Yuchen, Le, BaoChau, Korenchuk, Susan, Crouthamel, Ming-Chih, McHugh, Charles F., Vessella, Robert, Creasy, Caretha L., Tummino, Peter J., Barbash, Olena
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926837/
https://ncbi.nlm.nih.gov/pubmed/24293458
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