SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Deregulation in lysine methylation signaling has emerged as a common etiologic factor in cancer pathogenesis, with inhibitors of several histone lysine methyltransferases (KMTs) being developed as chemotherapeutics(1). The largely cytoplasmic KMT SMYD3 (SET and MYND domain containing protein 3) is o...

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Main Authors: Mazur, Pawel K., Reynoird, Nicolas, Khatri, Purvesh, Jansen, Pascal W.T.C., Wilkinson, Alex, Liu, Shichong, Barbash, Olena, Van Aller, Glenn S., Huddleston, Michael, Dhanak, Dashyant, Tummino, Peter J., Kruger, Ryan G., Garcia, Benjamin, Butte, Atul J., Vermeulen, Michiel, Sage, Julien, Gozani, Or
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122675/
https://ncbi.nlm.nih.gov/pubmed/24847881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13320
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