SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Deregulation in lysine methylation signaling has emerged as a common etiologic factor in cancer pathogenesis, with inhibitors of several histone lysine methyltransferases (KMTs) being developed as chemotherapeutics(1). The largely cytoplasmic KMT SMYD3 (SET and MYND domain containing protein 3) is o...

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Hlavní autoři: Mazur, Pawel K., Reynoird, Nicolas, Khatri, Purvesh, Jansen, Pascal W.T.C., Wilkinson, Alex, Liu, Shichong, Barbash, Olena, Van Aller, Glenn S., Huddleston, Michael, Dhanak, Dashyant, Tummino, Peter J., Kruger, Ryan G., Garcia, Benjamin, Butte, Atul J., Vermeulen, Michiel, Sage, Julien, Gozani, Or
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122675/
https://ncbi.nlm.nih.gov/pubmed/24847881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13320
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