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Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic options. We found that levels of the lysine methyltransferase SMYD2 (SET and MYND domain 2) are elevated in PDAC and that genetic and pharmacological inhibition of SMYD2 restricts PDAC growth. We further identifi...
Shranjeno v:
| izdano v: | Genes Dev |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4826394/ https://ncbi.nlm.nih.gov/pubmed/26988419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.275529.115 |
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