Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic options. We found that levels of the lysine methyltransferase SMYD2 (SET and MYND domain 2) are elevated in PDAC and that genetic and pharmacological inhibition of SMYD2 restricts PDAC growth. We further identifi...

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Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Reynoird, Nicolas, Mazur, Pawel K., Stellfeld, Timo, Flores, Natasha M., Lofgren, Shane M., Carlson, Scott M., Brambilla, Elisabeth, Hainaut, Pierre, Kaznowska, Ewa B., Arrowsmith, Cheryl H., Khatri, Purvesh, Stresemann, Carlo, Gozani, Or, Sage, Julien
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826394/
https://ncbi.nlm.nih.gov/pubmed/26988419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.275529.115
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