Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic options. We found that levels of the lysine methyltransferase SMYD2 (SET and MYND domain 2) are elevated in PDAC and that genetic and pharmacological inhibition of SMYD2 restricts PDAC growth. We further identifi...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Reynoird, Nicolas, Mazur, Pawel K., Stellfeld, Timo, Flores, Natasha M., Lofgren, Shane M., Carlson, Scott M., Brambilla, Elisabeth, Hainaut, Pierre, Kaznowska, Ewa B., Arrowsmith, Cheryl H., Khatri, Purvesh, Stresemann, Carlo, Gozani, Or, Sage, Julien
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826394/
https://ncbi.nlm.nih.gov/pubmed/26988419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.275529.115
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