Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is driven by mutations in PKD1 and PKD2 genes. Recent work suggests that epigenetic modulation of gene expression and protein function may play a role in ADPKD pathogenesis. In this study, we identified SMYD2, a SET and MYND domain protein with ly...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Li, Linda Xiaoyan, Fan, Lucy X., Zhou, Julie Xia, Grantham, Jared J., Calvet, James P., Sage, Julien, Li, Xiaogang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490754/
https://ncbi.nlm.nih.gov/pubmed/28604386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90921
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