Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is driven by mutations in PKD1 and PKD2 genes. Recent work suggests that epigenetic modulation of gene expression and protein function may play a role in ADPKD pathogenesis. In this study, we identified SMYD2, a SET and MYND domain protein with ly...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Li, Linda Xiaoyan, Fan, Lucy X., Zhou, Julie Xia, Grantham, Jared J., Calvet, James P., Sage, Julien, Li, Xiaogang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490754/
https://ncbi.nlm.nih.gov/pubmed/28604386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90921
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