Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is driven by mutations in PKD1 and PKD2 genes. Recent work suggests that epigenetic modulation of gene expression and protein function may play a role in ADPKD pathogenesis. In this study, we identified SMYD2, a SET and MYND domain protein with ly...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Li, Linda Xiaoyan, Fan, Lucy X., Zhou, Julie Xia, Grantham, Jared J., Calvet, James P., Sage, Julien, Li, Xiaogang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490754/
https://ncbi.nlm.nih.gov/pubmed/28604386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90921
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