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Characterization of an exosite binding inhibitor of matrix metalloproteinase 13
Matrix metalloproteinase 13 (MMP13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis. Clinical administration of broad spectrum MMP inhibitors such as marimastat has been implicated in severe musculo-skeletal side effects. Consequently, research has been fo...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2144595/ https://ncbi.nlm.nih.gov/pubmed/18042679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073130208 |
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