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Characterization of an exosite binding inhibitor of matrix metalloproteinase 13

Matrix metalloproteinase 13 (MMP13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis. Clinical administration of broad spectrum MMP inhibitors such as marimastat has been implicated in severe musculo-skeletal side effects. Consequently, research has been fo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gooljarsingh, Lata T., Lakdawala, Ami, Coppo, Frank, Luo, Lusong, Fields, Gregg B., Tummino, Peter J., Gontarek, Richard R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144595/
https://ncbi.nlm.nih.gov/pubmed/18042679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073130208
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