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Identification of Novel, Exosite-Binding Matrix Metalloproteinase-13 Inhibitor Scaffolds
Matrix metalloproteinase 13 (MMP-13) has been implicated as the protease responsible for collagen degradation in cartilage during osteoarthritis (OA). Compounds that inhibit the metalloproteinase at the Zn binding site typically lack specificity among MMP family members. Analogs of the low-micromola...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210410/ https://ncbi.nlm.nih.gov/pubmed/22018790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.077 |
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