Identification of Novel, Exosite-Binding Matrix Metalloproteinase-13 Inhibitor Scaffolds

Matrix metalloproteinase 13 (MMP-13) has been implicated as the protease responsible for collagen degradation in cartilage during osteoarthritis (OA). Compounds that inhibit the metalloproteinase at the Zn binding site typically lack specificity among MMP family members. Analogs of the low-micromola...

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Hlavní autoři: Roth, Joshua, Minond, Dmitriy, Darout, Etzer, Liu, Qin, Lauer, Janelle, Hodder, Peter, Fields, Gregg B., Roush, William R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210410/
https://ncbi.nlm.nih.gov/pubmed/22018790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.077
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