Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

[Image: see text] Matrix metalloproteinase 13 (MMP-13) has been shown to be the main collagenase responsible for degradation of articular cartilage during osteoarthritis and therefore represents a target for drug development. As a result of high-throughput screening and structure–activity relationsh...

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Pubblicato in:J Med Chem
Autori principali: Spicer, Timothy P., Jiang, Jianwen, Taylor, Alexander B., Choi, Jun Yong, Hart, P. John, Roush, William R., Fields, Gregg B., Hodder, Peter S., Minond, Dmitriy
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255739/
https://ncbi.nlm.nih.gov/pubmed/25330343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501284e
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