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High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate
The major components of the cartilage extracellular matrix are type II collagen and aggrecan. Matrix metalloproteinase 13 (MMP-13) has been implicated as the protease responsible for collagen degradation in cartilage during osteoarthritis (OA). In the present study, a triple-helical FRET substrate h...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3298815/ https://ncbi.nlm.nih.gov/pubmed/18358729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.03.004 |
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