Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does Not Influence NFκB Responses

SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellular assays both to assist in drug discovery efforts an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Grimley, Rachel, Polyakova, Oxana, Vamathevan, Jessica, McKenary, Joanne, Hayes, Brian, Patel, Champa, Smith, Janet, Bridges, Angela, Fosberry, Andrew, Bhardwaja, Anshu, Mouzon, Bernadette, Chung, Chun-Wa, Barrett, Nathalie, Richmond, Nicola, Modha, Sundip, Solari, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391194/
https://ncbi.nlm.nih.gov/pubmed/22792191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039847
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados