Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does Not Influence NFκB Responses

SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellular assays both to assist in drug discovery efforts an...

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Autores principales: Grimley, Rachel, Polyakova, Oxana, Vamathevan, Jessica, McKenary, Joanne, Hayes, Brian, Patel, Champa, Smith, Janet, Bridges, Angela, Fosberry, Andrew, Bhardwaja, Anshu, Mouzon, Bernadette, Chung, Chun-Wa, Barrett, Nathalie, Richmond, Nicola, Modha, Sundip, Solari, Roberto
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391194/
https://ncbi.nlm.nih.gov/pubmed/22792191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039847
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