Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Por Spinks, Daniel, Shanks, Emma J, Cleghorn, Laura A T, McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H
Publicado em 2009

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Le...

Por Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A T, Ojo, Kayode K, Van Voorhis, Wesley C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
Publicado em 2013

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Por Cleghorn, Laura A T, Woodland, Andrew, Collie, Iain T, Torrie, Leah S, Norcross, Neil, Luksch, Torsten, Mpamhanga, Chido, Walker, Roderick G, Mottram, Jeremy C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
Publicado em 2011

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Por Smith, Victoria C, Cleghorn, Laura A T, Woodland, Andrew, Spinks, Daniel, Hallyburton, Irene, Collie, Iain T, Yi Mok, N, Norval, Suzanne, Brenk, Ruth, Fairlamb, Alan H, Frearson, Julie A, Read, Kevin D, Gilbert, Ian H, Wyatt, Paul G
Publicado em 2011

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Por Cleghorn, Laura A. T., Albrecht, Sébastien, Stojanovski, Laste, Simeons, Frederick R. J., Norval, Suzanne, Kime, Robert, Collie, Iain T., De Rycker, Manu, Campbell, Lorna, Hallyburton, Irene, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.
Publicado no J Med Chem (2015)

Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis

Por Arora, Kriti, Ochoa-Montaño, Bernardo, Tsang, Patricia S., Blundell, Tom L., Dawes, Stephanie S., Mizrahi, Valerie, Bayliss, Tracy, Mackenzie, Claire J., Cleghorn, Laura A. T., Ray, Peter C., Wyatt, Paul G., Uh, Eugene, Lee, Jinwoo, Barry, Clifton E., Boshoff, Helena I.
Publicado no Antimicrob Agents Chemother (2014)

Correction for Arora et al., “Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis”

Por Arora, Kriti, Ochoa-Montaño, Bernardo, Tsang, Patricia S., Blundell, Tom L., Dawes, Stephanie S., Mizrahi, Valerie, Bayliss, Tracy, Mackenzie, Claire J., Cleghorn, Laura A. T., Ray, Peter C., Wyatt, Paul G., Uh, Eugene, Lee, Jinwoo, Barry, Clifton E., Boshoff, Helena I.
Publicado no Antimicrob Agents Chemother (2017)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

Por Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A T, Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A, Gray, David W, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H
Publicado no ChemMedChem (2015)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Por Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
Publicado em 2011

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Por Frearson, Julie A., Brand, Stephen, McElroy, Stuart P., Cleghorn, Laura A.T., Smid, Ondrej, Stojanovski, Laste, Price, Helen P., Guther, M. Lucia S., Torrie, Leah S., Robinson, David A., Hallyburton, Irene, Mpamhanga, Chidochangu P., Brannigan, James A., Wilkinson, Anthony J., Hodgkinson, Michael, Hui, Raymond, Qiu, Wei, Raimi, Olawale G., van Aalten, Daan M. F., Brenk, Ruth, Gilbert, Ian H., Read, Kevin D., Fairlamb, Alan H., Ferguson, Michael A. J., Smith, Deborah F., Wyatt, Paul G.
Publicado em 2010