Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

New drugs are urgently needed for the treatment of tropical parasitic diseases such as leishmaniasis and human African trypanosomiasis (HAT). This work involved a high-throughput screen of a focussed kinase set of ∼3400 compounds to identify potent and parasite-selective inhibitors of an enzymatic L...

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Bibliografische gegevens
Hoofdauteurs: Cleghorn, Laura A T, Woodland, Andrew, Collie, Iain T, Torrie, Leah S, Norcross, Neil, Luksch, Torsten, Mpamhanga, Chido, Walker, Roderick G, Mottram, Jeremy C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: WILEY-VCH Verlag 2011
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Full Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272345/
https://ncbi.nlm.nih.gov/pubmed/21913331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100344
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