The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824

Nitroimidazole PA-824 is part of an exciting new class of compounds currently undergoing clinical evaluation as novel TB therapeutics. The recently elucidated mechanism of action of PA-824 involves reduction of the nitroimidazole ring and subsequent nitric oxide release. The importance of this compo...

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Bibliographic Details
Main Authors: Bollo, Soledad, Núñez-Vergara, Luis J., Kang, Sunhee, Zhang, Liang, Boshoff, Helena I., Barry, Clifton E., Squella, Juan A., Dowd, Cynthia S.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021465/
https://ncbi.nlm.nih.gov/pubmed/21168331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.093
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