Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

PA-824 is a promising new compound for the treatment of tuberculosis that is currently undergoing human trials. Like its progenitors metronidazole and CGI-17341, PA-824 is a prodrug of the nitroimidazole class, requiring bioreductive activation of an aromatic nitro group to exert an antitubercular e...

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Detalhes bibliográficos
Main Authors: Manjunatha, Ujjini H., Boshoff, Helena, Dowd, Cynthia S., Zhang, Liang, Albert, Thomas J., Norton, Jason E., Daniels, Lacy, Dick, Thomas, Pang, Siew Siew, Barry, Clifton E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326169/
https://ncbi.nlm.nih.gov/pubmed/16387854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508392103
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