Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824

Nitroimidazoles such as PA-824 and OPC-67683 are currently in clinical development as members of a promising new class of therapeutics for tuberculosis. While the antitubercular activity of these compounds is high, they both suffer from poor water solubility thus complicating development. We determi...

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Main Authors: Li, Xiaojin, Manjunatha, Ujjini H., Goodwin, Michael B., Knox, John E., Lipinski, Christopher A., Keller, Thomas H., Barry, Clifton E., Dowd, Cynthia S.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408714/
https://ncbi.nlm.nih.gov/pubmed/18358721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.03.011
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