Structure-Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824)

The (S)-2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine named PA-824 (1) has demonstrated antitubercular activity in vitro and in animal models and is currently in clinical trials. We synthesized derivatives at three positions of the 4-(trifluoromethoxy)benzylamin...

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Xehetasun bibliografikoak
Egile Nagusiak: Cherian, Joseph, Choi, Inhee, Nayyar, Amit, Manjunatha, Ujjini H., Mukherjee, Tathagata, Lee, Yong Sok, Boshoff, Helena I., Singh, Ramandeep, Ha, Young Hwan, Goodwin, Michael, Lakshminarayana, Suresh B., Niyomrattanakit, Pornwaratt, Jiricek, Jan, Ravindran, Sindhu, Dick, Thomas, Keller, Thomas H., Dartois, Veronique, Barry, Clifton E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158291/
https://ncbi.nlm.nih.gov/pubmed/21755942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1010644
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