Substrate specificity of the Deazaflavin-Dependent Nitroreductase (Ddn) from Mycobacterium tuberculosis Responsible for the Bioreductive Activation of Bicyclic Nitroimidazoles

The bicyclic 4-nitroimidazoles PA-824 and OPC-67683 represent a promising novel class of therapeutics for tuberculosis (TB) and are currently in phase II clinical development. Both compounds are pro-drugs that are reductively activated by a deazaflavin (F(420)) dependent nitroreductase (Ddn). Herein...

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Detaylı Bibliyografya
Asıl Yazarlar: Gurumurthy, Meera, Mukherjee, Tathagata, Dowd, Cynthia S., Singh, Ramandeep, Niyomrattanakit, Pornwaratt, Tay, Jo Ann, Nayyar, Amit, Lee, Yong Sok, Cherian, Joseph, Boshoff, Helena I., Dick, Thomas, Barry, Clifton E., Manjunatha, Ujjini H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444742/
https://ncbi.nlm.nih.gov/pubmed/22023140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2011.08404.x
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