A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism

Por Manjunatha, Ujjini H., Maxwell, Anthony, Nagaraja, Valakunja
Publicado em 2005

Mycobacterium leprae Is Naturally Resistant to PA-824

Por Manjunatha, Ujjini H., Lahiri, Ramanuj, Randhawa, Baljit, Dowd, Cynthia S., Krahenbuhl, James L., Barry, Clifton E.
Publicado em 2006

A novel F(420)-dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents

Por Gurumurthy, Meera, Rao, Martin, Mukherjee, Tathagata, Rao, Srinivasa P S, Boshoff, Helena I, Dick, Thomas, Barry, Clifton E, Manjunatha, Ujjini H
Publicado em 2013

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824

Por Li, Xiaojin, Manjunatha, Ujjini H., Goodwin, Michael B., Knox, John E., Lipinski, Christopher A., Keller, Thomas H., Barry, Clifton E., Dowd, Cynthia S.
Publicado em 2008

Structure-activity relationships of antitubercular nitroimidazoles. I. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles

Por Kim, Pilho, Zhang, Liang, Manjunatha, Ujjini H., Singh, Ramandeep, Patel, Sejal, Jiricek, Jan, Keller, Thomas H., Boshoff, Helena I., Barry, Clifton E., Dowd, Cynthia S.
Publicado em 2009

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

Por Manjunatha, Ujjini H., Boshoff, Helena, Dowd, Cynthia S., Zhang, Liang, Albert, Thomas J., Norton, Jason E., Daniels, Lacy, Dick, Thomas, Pang, Siew Siew, Barry, Clifton E.
Publicado em 2006

Substrate specificity of the Deazaflavin-Dependent Nitroreductase (Ddn) from Mycobacterium tuberculosis Responsible for the Bioreductive Activation of Bicyclic Nitroimidazoles

Por Gurumurthy, Meera, Mukherjee, Tathagata, Dowd, Cynthia S., Singh, Ramandeep, Niyomrattanakit, Pornwaratt, Tay, Jo Ann, Nayyar, Amit, Lee, Yong Sok, Cherian, Joseph, Boshoff, Helena I., Dick, Thomas, Barry, Clifton E., Manjunatha, Ujjini H.
Publicado em 2011

Structure-Activity Relationships of Antitubercular Nitroimidazoles. II. Determinants of aerobic activity and quantitative structure-activity relationships

Por Kim, Pilho, Kang, Sunhee, Boshoff, Helena I., Jiricek, Jan, Collins, Margaret, Singh, Ramandeep, Manjunatha, Ujjini H., Niyomrattanakit, Pornwaratt, Zhang, Liang, Goodwin, Michael, Dick, Thomas, Keller, Thomas H., Dowd, Cynthia S., Barry, Clifton E.
Publicado em 2009

Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

Por Lakshminarayana, Suresh B., Boshoff, Helena I. M., Cherian, Joseph, Ravindran, Sindhu, Goh, Anne, Jiricek, Jan, Nanjundappa, Mahesh, Nayyar, Amit, Gurumurthy, Meera, Singh, Ramandeep, Dick, Thomas, Blasco, Francesca, Barry, Clifton E., Ho, Paul C., Manjunatha, Ujjini H.
Publicado em 2014

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberc...

Por Kim, Pilho, Zhang, Yong-Mei, Shenoy, Gautham, Nguyen, Quynh-Anh, Boshoff, Helena I., Manjunatha, Ujjini H., Goodwin, Michael, Lonsdale, John, Price, Allen C., Miller, Darcie J., Duncan, Ken, White, Stephen W., Rock, Charles O., Barry, Clifton E., Dowd, Cynthia S.
Publicado em 2006

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

Por Cellitti, Susan E., Shaffer, Jennifer, Jones, David H., Mukherjee, Tathagata, Gurumurthy, Meera, Bursulaya, Badry, Boshoff, Helena I., Choi, Inhee, Nayyar, Amit, Lee, Yong Sok, Cherian, Joseph, Niyomrattanakit, Pornwaratt, Dick, Thomas, Manjunatha, Ujjini H., Barry, Clifton E., Spraggon, Glen, Geierstanger, Bernhard H.
Publicado em 2012

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

Por Cellitti, Susan E., Shaffer, Jennifer, Jones, David H., Mukherjee, Tathagata, Gurumurthy, Meera, Bursulaya, Badry, Boshoff, Helena I., Choi, Inhee, Nayyar, Amit, Lee, Yong Sok, Cherian, Joseph, Niyomrattanakit, Pornwaratt, Dick, Thomas, Manjunatha, Ujjini H., Barry, Clifton E., Spraggon, Glen, Geierstanger, Bernhard H.
Publicado no Structure (2013)

Structure-Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-...

Por Cherian, Joseph, Choi, Inhee, Nayyar, Amit, Manjunatha, Ujjini H., Mukherjee, Tathagata, Lee, Yong Sok, Boshoff, Helena I., Singh, Ramandeep, Ha, Young Hwan, Goodwin, Michael, Lakshminarayana, Suresh B., Niyomrattanakit, Pornwaratt, Jiricek, Jan, Ravindran, Sindhu, Dick, Thomas, Keller, Thomas H., Dartois, Veronique, Barry, Clifton E.
Publicado em 2011

Direct inhibitors of InhA active against Mycobacterium tuberculosis

Por Manjunatha, Ujjini H., Rao, Srinivasa P. S., Kondreddi, Ravinder Reddy, Noble, Christian G., Camacho, Luis R., Tan, Bee H., Ng, Seow H., Ng, Pearly Shuyi, Ma, N. L., Lakshminarayana, Suresh B., Herve, Maxime, Barnes, S. Whitney, Yu, Weixuan, Kuhen, Kelli, Blasco, Francesca, Beer, David, Walker, John R., Tonge, Peter J., Glynne, Richard, Smith, Paul W., Diagana, Thierry T.
Publicado no Sci Transl Med (2015)

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

Por Manjunatha, Ujjini H., Vinayak, Sumiti, Zambriski, Jennifer A., Chao, Alexander T., Sy, Tracy, Noble, Christian G., Bonamy, Ghislain M. C., Kondreddi, Ravinder R., Zou, Bin, Gedeck, Peter, Brooks, Carrie F., Herbert, Gillian T., Sateriale, Adam, Tandel, Jayesh, Noh, Susan, Lakshminarayana, Suresh B., Lim, Siau H., Goodman, Laura B., Bodenreider, Christophe, Feng, Gu, Zhang, Lijun, Blasco, Francesca, Wagner, Juergen, Leong, F. Joel, Striepen, Boris, Diagana, Thierry T.
Publicado no Nature (2017)