Direct inhibitors of InhA active against Mycobacterium tuberculosis

New chemotherapeutic agents are urgently required to combat the global spread of multi-drug resistant tuberculosis (MDR-TB). The mycobacterial enoyl reductase, InhA, is one of the few clinically-validated targets in tuberculosis drug discovery. Here, we report the identification of a new class of di...

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Bibliografiske detaljer
Udgivet i:Sci Transl Med
Main Authors: Manjunatha, Ujjini H., Rao, Srinivasa P. S., Kondreddi, Ravinder Reddy, Noble, Christian G., Camacho, Luis R., Tan, Bee H., Ng, Seow H., Ng, Pearly Shuyi, Ma, N. L., Lakshminarayana, Suresh B., Herve, Maxime, Barnes, S. Whitney, Yu, Weixuan, Kuhen, Kelli, Blasco, Francesca, Beer, David, Walker, John R., Tonge, Peter J., Glynne, Richard, Smith, Paul W., Diagana, Thierry T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383039/
https://ncbi.nlm.nih.gov/pubmed/25568071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010597
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