Direct inhibitors of InhA active against Mycobacterium tuberculosis

New chemotherapeutic agents are urgently required to combat the global spread of multi-drug resistant tuberculosis (MDR-TB). The mycobacterial enoyl reductase, InhA, is one of the few clinically-validated targets in tuberculosis drug discovery. Here, we report the identification of a new class of di...

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Bibliografiset tiedot
Julkaisussa:Sci Transl Med
Päätekijät: Manjunatha, Ujjini H., Rao, Srinivasa P. S., Kondreddi, Ravinder Reddy, Noble, Christian G., Camacho, Luis R., Tan, Bee H., Ng, Seow H., Ng, Pearly Shuyi, Ma, N. L., Lakshminarayana, Suresh B., Herve, Maxime, Barnes, S. Whitney, Yu, Weixuan, Kuhen, Kelli, Blasco, Francesca, Beer, David, Walker, John R., Tonge, Peter J., Glynne, Richard, Smith, Paul W., Diagana, Thierry T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383039/
https://ncbi.nlm.nih.gov/pubmed/25568071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010597
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