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Rational modulation of the induced-fit conformational change for slow-onset inhibition in M. tuberculosis InhA
Slow-onset enzyme inhibitors are the subject of considerable interest as an approach to increase potency of pharmaceutical compounds by extending the residence time of the inhibitor on the target (the lifetime of the drug-receptor complex). However, rational modulation of residence time presents sig...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4805124/ https://ncbi.nlm.nih.gov/pubmed/26147157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00284 |
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