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A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis

InhA, the enoyl-ACP reductase in Mycobacterium tuberculosis is an attractive target for the development of novel drugs against tuberculosis, a disease that kills more than two million people each year. InhA is the target of the current first line drug isoniazid for the treatment of tuberculosis infe...

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Détails bibliographiques
Auteurs principaux: Luckner, Sylvia R., Liu, Nina, am Ende, Christopher W., Tonge, Peter J., Kisker, Caroline
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863195/
https://ncbi.nlm.nih.gov/pubmed/20200152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090373
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