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Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides

InhA, the enoyl acyl carrier protein reductase (ENR) from Mycobacterium tuberculosis, is one of the key enzymes involved in the type II fatty acid biosynthesis pathway of M. tuberculosis. We report here the discovery, through high-throughput screening, of a series of arylamides as a novel class of p...

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Hlavní autoři: He, Xin, Alian, Akram, Ortiz de Montellano, Paul R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2020492/
https://ncbi.nlm.nih.gov/pubmed/17723305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.08.013
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