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Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides

InhA, the enoyl acyl carrier protein reductase (ENR) from Mycobacterium tuberculosis, is one of the key enzymes involved in the type II fatty acid biosynthesis pathway of M. tuberculosis. We report here the discovery, through high-throughput screening, of a series of arylamides as a novel class of p...

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Bibliografski detalji
Glavni autori: He, Xin, Alian, Akram, Ortiz de Montellano, Paul R.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2020492/
https://ncbi.nlm.nih.gov/pubmed/17723305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.08.013
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