Biological Evaluation of Potent Triclosan-Derived Inhibitors of the Enoyl-Acyl Carrier Protein Reductase InhA in Drug-sensitive and Drug-resistant Strains of Mycobacterium tuberculosis

New triclosan (TRC) analogs were evaluated for their activity against the enoyl-acyl carrier protein reductase InhA in Mycobacterium tuberculosis (Mtb). TRC is a well-known inhibitor of InhA and specific modifications to its positions 5 and 4′ afforded twenty-seven derivatives; of these compounds se...

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Hlavní autoři: Stec, Jozef, Vilchèze, Catherine, Lun, Shichun, Perryman, Alexander L., Wang, Xin, Freundlich, Joel S., Bishai, William, Jacobs, William R., Kozikowski, Alan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213240/
https://ncbi.nlm.nih.gov/pubmed/25165007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402255
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