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The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: Adduct affinity and drug resistance

Isoniazid (INH), a frontline antitubercular drug, inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. Here, we report that the INH-NAD adduct is a slow, tight-binding competitive inhibitor of InhA. Demonstration that the adduct bind...

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Detalhes bibliográficos
Main Authors: Rawat, Richa, Whitty, Adrian, Tonge, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283515/
https://ncbi.nlm.nih.gov/pubmed/14623976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235848100
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