The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: Adduct affinity and drug resistance

Lignende værker

• Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis
  af: Kruh, Nicole A., et al.
  Udgivet: (2007)
• A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis
  af: Luckner, Sylvia R., et al.
  Udgivet: (2010)
• A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA
  af: Li, Huei-Jiun, et al.
  Udgivet: (2014)
• InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis
  af: Vögeli, Bastian, et al.
  Udgivet: (2018)
• Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds
  af: Pan, Pan, et al.
  Udgivet: (2012)