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Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis

The frontline tuberculosis drug isoniazid (INH) inhibits InhA, the NADH-dependent fatty acid biosynthesis (FAS-II) enoyl reductase from Mycobacterium tuberculosis (MTB), via formation of a covalent adduct with NAD(+) (the INH-NAD adduct). Resistance to INH can be correlated with many mutations in MT...

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Main Authors: Kruh, Nicole A., Rawat, Richa, Ruzsicska, Béla P., Tonge, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203378/
https://ncbi.nlm.nih.gov/pubmed/17600151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062749007
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